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Jon  Antilla

Jon Antilla

Jon Antilla


Office: NES 230
Phone: 813/974-7438
Lab: NES 332



B.S., Northern Michigan University, 1995
Ph.D., University of Chicago, 2000
Postdoctoral Fellow (NIH-NCI), Massachusetts Institute of Technology, 2000-2003


Chiral Organocatalysis, Metal-Catalysis, New Stereoselective Reaction Methodology, Drug Discovery.

We now made significant inroads into a new area of organocatalysis that utilize chiral phosphoric acids and chiral metal phosphate complexes in a number of interesting synthetic transformations. We have published the first examples in the literature where chiral N,N- or N,O-aminals can be formed in a catalytic enantioselective manner. This new approach to catalysis has allowed for the general synthesis of highly desired chiral heterocycles. We have also collaborated with the medical center to develop drugs for post-stroke treatment. These potential drugs are based upon a promising lead structure with a guanidine core. We have developed synthetic routes to synthetic guanidine analogues.

Current Funding

View our currently funded projects here.

Ongoing Research Support

Title: The development of New Stereoselective Organocatalytic Processes (Sole PI)
Agency: NIH - $ 1,318,849.00 - 9/1/08-8/31/13
Type: R01 (GM082935) (Sole PI)

Title: Chiral Phosphoric Acid-Catalyzed Reaction Methodology and Synthetic Applications
Agency: NSF - $ 550,000 - 4/1/09-3/31/14
Type: CAREER (CHE-0847108) (Sole PI)

Completed Research Support

Title: Synthesis and Screening of Sigma Receptor Ligands for Stroke Therapy at Delayed Time Points
Agency: FCoE-BITT (Co-PI on this seed grant) - $ 75,000 - 2/1/08-1/31/09
Type: Internal Grant

Title: Brønsted Acid-Catalyzed Asymmetric Additions to Imines (Sole PI)
Agency: PRF - $ 40,000.00 - 1/1/07-8/31/09
Type: Type G Starter (PRF# 45899-G1) (Sole PI)

Title: Novel Neuronal Nicotinic Receptor Modulators for the Treatment of Ataxia
Agency: FCoE-BITT - $ 70,000 - 5/1/09-4/30/10
Type: Internal Grant (Co-PI on this seed grant)

Title: Synthesis and Screening of Sigma Ligands for Stroke Treatment at Delayed Time Points
Agency: James and Ester King Biomedical Research - $ 999,360 - 7/1/09-6/30/11
Type: Florida Department of Health State Grant (Co-PI on this Team Science Grant)

Postdoctoral Associates and Visiting Scholars

Dr. Zhongang Mu, Dr. Guilong Li, Dr. Zuhui Zhang