banner USF Home College of Arts & Sciences OASIS myUSF USF A-Z Index

USF Home > College of Arts and Sciences > Chemistry Department

James  Leahy

James Leahy

James Leahy
Professor

Contact

Office:
Phone: 813/974-4642
Email:

Education

B.S., University of South Florida
Ph.D., University of South Florida
Postdoctoral Fellow, University of Pennsylvania

Professional Experience

University of California, Berkeley, Assistant Professor, 1992 – 1998
MetaXen, Director of Chemistry, 1998 – 1999
Exelixis, Senior Director of Chemistry, 1999 - 2011

Research

The ultimate goal of the research in our labs is the discovery of new drug candidates with fully optimized pharmacokinetic and pharmacodynamics parameters. Professor Leahy has extensive experience in this area, having advanced more than a dozen compounds into human clinical trials including the discovery of Cometriq/Cabozantinib/XL184. Toward this end, the Leahy group is actively engaged in collaborative research efforts aimed at the synthesis and optimization of small molecule leads in a number of therapeutic areas as well as the pursuit of novel synthetic methodology.

Graduate Students

Linda Barbeto, Benjamin Eduful, Ankush Kanwar

Specialty Area

Organic/Medicinal Chemistry

Recent Publications and Patents

“SAR and in vivo Evaluation of 4-Aryl-2-aminoalkylpyrimidines as Potent and Selective Janus Kinase 2 (JAK2) Inhibitors,” Timothy Forsyth, Patrick C. Kearney, Byung Gyu Kim, Henry W. B. Johnson, Naing Aay, Arlyn Arcalas, David S. Brown, Vicky Chan, Jeff Chen, Hongwang Du, Sergey Epshteyn, Adam A. Galan, Tai P. Huynh, Mohamed A. Ibrahim, Brian Kane, Elena S. Koltun, Grace Mann, Lisa E. Meyr, Matthew S. Lee, Gary L. Lewis, Robin T. Noguchi, Michael Pack, Brian H. Ridgway, Xian Shi, Craig S. Takeuchi, Peiwen Zu, James W. Leahy, John M. Nuss, Ron Aoyama, Stefan Engst, Steven B. Gendreau, Robert Kassees, Jia Li, Shwu-Hwa Lin, Jean-Francois Martini, Thomas Stout, Philip Tong, John Woolfrey, Wentao Zhang and Peiwen Yu, Bioorg. Med. Chem. Lett. 2012, 22, 7653.

“Discovery of a Novel Series of Potent and Orally Bioavailable Phosphoinositide 3-Kinase γ Inhibitors,” James W. Leahy, Chris A. Buhr, Henry W. B. Johnson, Byung Gyu Kim, TaeGon Baik, Jonah Cannoy, Timothy P. Forsyth, Joon Won Jeong, Matthew S. Lee, Sunghoon Ma, Kevin Noson, Longcheng Wang, Matthew Williams, John M. Nuss, Eric Brooks, Paul Foster, Leanne Goon, Nathan Heald, Charles Holst, Christopher Jaeger, Scott Lam, Julie Lougheed, Lam Nguyen, Arthur Plonowski, Joanne Song, Thomas Stout, Xiang Wu, Michael F. Yakes, Peiwen Yu, Wentao Zhang, Peter Lamb and Olivia Raeber, J. Med. Chem. 2012, 55, 5467.

“The Discovery of a Novel Class of Potent and Orally Bioavailable Sphingosine-1-Phosphate Receptor 1 Antagonists,” Mohamed A. Ibrahim, Henry W. B. Johnson, Joon Won Jeong, Gary L. Lewis, Xian Shi, Robin T. Noguchi, Matthew Williams, James W. Leahy, John M. Nuss, John Woolfrey, Monica Ganica, Frauke Bentzien, Yu-Chien Chou, Anna Gibson, Nathan Heald, Peter Lamb, Larry Mattheakis, David Matthews, Aaron Shipway, Xiang Wu, WenTao Zhang, Sihong Zhou and Geetha Shankar, J. Med. Chem. 2012, 55, 1368.

“Inhibitors of Hedgehog Pathway,” Suleyman Bahceci, William Bajjalieh, Jeff Chen, Sergey Epshteyn, Timothy Patrick Forsyth, Tai Phat Huynh, Byung Gyu Kim, James W. Leahy, Matthew Sangyup Lee, Gary L. Lewis, Morrison B. Mac, Grace Mann, Charles K. Marlowe, Brian Hugh Ridgway, Joan C. Sangalang, Xian Shi, Craig Stacy Takeuchi and Yong Wang. U. S. Patent # 8,222,263, July 17, 2012.

“Pyrimidine Derivatives as Kinase Modulators and Method of Use,” Jeff Chen, Lisa Esther Dalrymple, Sergey Epshteyn, Timothy Patrick Forsyth, Tai Phat Huynh, Mohamed Abdulkader Ibrahim, James W. Leahy, Gary Lee Lewis, Grace Mann, Larry W. Mann, Robin Tammie Noguchi, Brian Hugh Ridgway, Joan Cruz Sangalang, Kevin Luke Schnepp, Xian Shi, Craig Stacy Takeuchi, Matthew Alan Williams, John Nuss and Atwood K. Cheung. U. S. Patent # 8,211,929, July 3, 2012.

“Tie-2 Modulators and Methods of Use,” Jeff Chen, Lisa Esther Dalrymple, Sergey Epshteyn, Timothy Patrick Forsyth, Tai Phat Huynh, James William Leahy, Brian Hugh Ridgway, Grace Mann, Larry W. Mann, Brian Ridgway, Craig Stacy Takeuchi and Joan C. Sangalang, U. S. Patent # 8,178,570, May 15, 2012.

“c-Met Modulators and Methods of Use,” Lynne Canne Bannen, Diva Sze-Ming Chan, Timothy Patrick Forsyth, Richard George Khoury, James William Leahy, Morrison B. Mac, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Yong Wang and Wei Xu, U. S. Patent # 8,178,532, May 15, 2012.

“JAK-2 Modulators and Methods of Use,” Adam Antoni Galan, Jeff Chen, Hongwang Du, Timothy Forsyth, Tai Phat Huynh, Henry William Beecroft Johnson, Patrick Kearney, James W. Leahy, Matthew Sangyup Lee, Grace Mann, Brian Hugh Ridgway, Craig Stacy Takeuchi and Peiwen Zhou, U. S. Patent # 8,088,767, January 3, 2012.

“Inhibitors of PI3K-delta and Methods of Their Use and Manufacture,” James William Leahy, PCT WO2012037204.

“c-Met Modulators and Methods of Use,” Lynne Canne Bannen, Diva Sze-Ming Chan, Timothy Patrick Forsyth, Richard George Khoury, James William Leahy, Morrison B. Mac, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Yong Wang and Wei Xu, European Patent # 2,392,565, December 7, 2011.

“c-Met Modulators and Methods of Use,” Lynne Canne Bannen, Diva Sze-Ming Chan, Jeff Chen, Lisa Esther Dalrymple, Timothy Patrick Forsyth, Tai Phat Huynh, Vasu Jammalamadaka, Richard George Khoury, James William Leahy, Morrison B. Mac, Grace Mann, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Craig Stacy Takeuchi, Yong Wang and Wei Xu, European Patent # 2,392,564, December 7, 2011.

“c-Met Modulators and Methods of Use,” Lynne Canne Bannen, Diva Sze-Ming Chan, Jeff Chen, Lisa Esther Dalrymple, Timothy Patrick Forsyth, Tai Phat Huynh, Vasu Jammalamadaka, Richard George Khoury, James William Leahy, Morrison B. Mac, Grace Mann, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Craig Stacy Takeuchi, Yong Wang and Wei Xu, U. S. Patent # 8,067,436, November 29, 2011.

“Tie-2 Modulators and Methods of Use,” Lynne Canne Bannen, S. David Brown, Wei Cheng, Vasu Jammalamadaka, John M. Nuss, Morrison B. Mac, Jason Jevious Parks, Matthew A. Williams, Wei Xu, Atwood Kim Cheung, Lisa Esther Dalrymple, Sergey Epshteyn, Mohamed Abdulkader Ibrahim, James William Leahy, Gary Lee Lewis, Robin Tammie Noguchi, Larry Wayne Mann, Brian Hugh Ridgway, Joan C. Sangalang, Kevin Luke Schnepp, Xian Shi and Richard George Khoury, U. S. Patent # 8,013,156, September 6, 2011.

“Sphingosine-1-Phosphate Receptor Antagonists,” Mohamed Abdulkader Ibrahim, Joon Won Jeong, Henry William Beecroft Johnson, Patrick Kearney, James W. Leahy, Gary L. Lewis, Robin Tammie Noguchi and John M. Nuss, European Patent # 2,346,821, July 27, 2011.

“c-Met Modulators and Methods of Use,” Lynne Canne Bannen, Diva Sze-Ming Chan, Lisa Esther Dalrymple, Vasu Jammalamadaka, Richard George Khoury, James William Leahy, Morrison B. Mac, Grace Mann, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Yong Wang and Wei Xu, U. S. Patent # 7,977,345, July 12, 2011.

“Anaplastic Lymphoma Kinase Modulators and Methods of Use,” James William Leahy, Gary Lee Lewis, John M. Nuss, Brian Hugh Ridgway and Joan C. Sangalang, U. S. Patent # 7,973,061, July 5, 2011.

“Tie-2 Modulators and Methods of Use,” Mohamed Ibrahim, James William Leahy, Joan C. Sangalang, Kevin Luke Schnepp, Xian Shi and John M. Nuss, U. S. Patent # 7,763,627, July 27, 2010.

“Protein Kinase Modulators and Methods of Use,” Chris A. Buhr, Tae-Gon Baik, Sunghoon Ma, Zerom Tesfai, Longcheng Wang, Erick Wang Co, Sergey Epshteyn, Abigail R. Kennedy, Baili Chen, Larisa Dubenko, Neel Kumar Anand, Tsze H. Tsang, John M. Nuss, Csaba J. Peto, Kenneth D. Rice, Mohamed Abdulkader Ibrahim, Kevin Luke Schnepp, Xian Shi, James William Leahy, Jeff Chen, Lisa Esther Dalrymple, Timothy Patrick Forsyth, Tai Phat Huynh, Grace Mann, Larry Wayne Mann, Craig Stacy Takeuchi, Peter Lamb, David J. Matthews and Nicole Miller, U. S. Patent # 7,704,995, April 27, 2010.

Current Courses

RefCourseSecCourse TitleCRDayTimeLocation
94772IDS 4914068Adv Undergrad Research Exp
0
TBA TBA
91069CHM 4932006Introduction to Drug Discovery
Pre-reqs: CHM 2210, CHM 2211, BSC 2010, BSC 2011.
3TR5:00pm-6:15pm
CHE 217
83629CHM 4970014Undergraduate Research
Requires Instructor Approval S-U Only.
1-3
TBA TBA
91070CHM 6938009Introduction to Drug Discovery
3TR5:00pm-6:15pm
CHE 217
91525CHM 6971014Thesis: Master's
S-U Only
2-19
TBA TBA
85003CHM 6973014Directed Research
S-U Only
1-19
TBA TBA
85010CHM 7820014Directed Research
S-U Only
1-19
TBA TBA
85019CHM 7980014Dissertation: Doctoral
Adm To Doc Candidacy Req, S-U Only
2-19
TBA TBA