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Roman  Manetsch

Roman Manetsch

Roman Manetsch
Courtesy Professor




Personal Bio



Diploma in Chemistry, University of Basel (Switzerland), 1998
Ph.D., University of Basel (Switzerland), 2002
Postdoctoral Fellow, The Scripps Research Institute (La Jolla, CA), 2002-2005

Specialty Area


Recent Journal Articles


Honors and Award






Recent Publications

  1. Nacheva K P, Maza W, Mayer D Z, Fronczek F, Larsen R W, Manetsch R*. Fluorescent Properties and Resonance Energy Transfer of 3,4-bis(2,4-difluorophenyl)-maleimide. Submitted.
  2. Kumar A B, Anderson J M, Melendez A L, Manetsch R*. Synthesis and structure-activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors. Submitted.
  3. Namelikonda N K, Manetsch R*. Sulfo-click reaction via in situ generated thioacids and its application in kinetic target-guided synthesis. Chem Commun 2012; 48, 1526-1528.
    Article has been published in the "Emerging Investigators 2012" issue.
  4. Cross R M, Namelikonda N K, Mutka T S, Luong L, Kyle D E, Manetsch R*. Synthesis, Antimalarial Activity, and Structure–Activity Relationship of 7-(2-Phenoxyethoxy)-4(1H)-quinolones. J Med Chem 2011; 54, 8321-8327.
  5. Kumar A B, Anderson J, Manetsch, R*. Design, Synthesis and Photoactivation Studies of Fluorous Photolabels. Org Biomol Chem 2011; 9, 6284-6292.
  6. Kulkarni S S, Hu X-D, Doi K, Wang H-G, Manetsch R*. Screening of Protein-Protein Interaction Modulators via Sulfo-Click Kinetic Target-Guided Synthesis. ACS Chemical Biology 2011; 6, 724-732.
    Appeared in the list of 20 "most read" ACS Chemical Biology articles in 2011.
  7. Cross M R, Maignan J R, Mutka T S, Luong L, Sargent J, Kyle D K, Manetsch R*. Optimization of 1,2,3,4-Tetrahydroacridin-9(10H)-ones as Antimalarials Utilizing Structure-Activity and Structure-Property Relationships. J Med Chem 2011; 54, 4399-4426.
  8. Cross R M, Manetsch R*. Divergent Route to Access Structurally Diverse 4-Quinolones via Mono or Sequential Cross-Couplings. J Org Chem 2010; 75, 8654-8657.
  9. Cross M R, Monastyrskyi A, Mutka T S, Burrows J, Kyle D K, Manetsch R*. Endochin Optimization: Structure-Activity and Structure-Property Relationship Studies of 3-substituted 2-Methyl-3(1H)-quinolones with Antimalarial Activity. J Med Chem 2010; 53, 7076-7094.
  10. Hu. X. Manetsch R*. Kinetic Target-Guided Synthesis. Chem Soc Rev 2010, 39, 1316-1324.
  11. Radic Z, Manetsch R, Fournier D, Sharpless KB, Taylor P*. Probing Gorge Dimensions of Cholinesterases by Freeze-Frame Click Chemistry. Chem-Biol Interact 2008; 175: 161-165.
  12. Hu X, Sun J, Wang H-G, Manetsch R*. Bcl-XL-Templated Assembly of its Own Protein-Protein Interaction Modulator from Fragments Decorated with Thio Acids and Sulfonyl Azides. J Am Chem Soc 2008; 130: 13820-13821.
  13. Sharpless KB, Manetsch R*. In Situ Click Chemistry: A Powerful Means for Lead Discovery (Review). Expert Opinion on Drug Discovery 2006; 1: 525-538.