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Department of Chemistry

Mark L. McLaughlin

Mark L. McLaughlin

Mark L. McLaughlin
Professor of Chemistry and Interdisciplinary Oncology

Contact Information

Department of Chemistry
University of South Florida
4202 E. Fowler Avenue, CHE 205A
Tampa, FL 33620-5250

Office: (813) 974-0014, NES 405A
Lab: (813) 974-7365, NES 405
Email: mmclaugh@cas.usf.edu

Education

B.S. in Chemistry, Christian Brothers College, Memphis, TN, 1979
Ph.D. in Organic Chemistry, Georgia Institute of Technology, 1983
Dissertation: Synthesis and Reactions of Aroylphosphides and Lewis Acid Catalyzed Aldol Condensations
Advisor: Charles L. Liotta
Postdoctoral Research -
Physical Organic Chemistry, Rice University, 1983-85
Mentor: Edward S. Lewis
Postdoctoral Research -
Synthetic Organic Chemistry, The Ohio State University, 1985-86
Mentor: Leo A. Paquette

Research Areas

We are investigating: short highly helical amphipathic peptides with direct and indirect antimicrobial activity and anticancer activity and constrained dipeptides that enforce an extended conformation for use in the synthesis of stable beta-sheet-like peptide structures with applications to age-related disease such as Alzheimer's and Parkinson's disease. We are developing a new class of HIV protease inhibitors based on easily synthesized constrained dipeptide-like units using a structure-based approach.

Graduate Researchers

Laura Anderson, David Badger, Priyesh Jain, Philip Murray, Melissa Topper, Mingzhou Zhou