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Mark McLaughlin

Mark McLaughlin

Mark McLaughlin
Professor of Chemistry and Interdisciplinary Oncology

Contact

Office: NES 405A
Lab: NES 405
Phone: 813/974-0014
Email:

Links

Education

B.S. in Chemistry, Christian Brothers College, Memphis, TN, 1979
Ph.D. in Organic Chemistry, Georgia Institute of Technology, 1983
Dissertation: Synthesis and Reactions of Aroylphosphides and Lewis Acid Catalyzed Aldol Condensations
Advisor: Charles L. Liotta
Postdoctoral Research -
Physical Organic Chemistry, Rice University, 1983-85
Mentor: Edward S. Lewis
Postdoctoral Research -
Synthetic Organic Chemistry, The Ohio State University, 1985-86
Mentor: Leo A. Paquette

Research

We are investigating: short highly helical amphipathic peptides with direct and indirect antimicrobial activity and anticancer activity and constrained dipeptides that enforce an extended conformation for use in the synthesis of stable beta-sheet-like peptide structures with applications to age-related disease such as Alzheimer's and Parkinson's disease. We are developing a new class of HIV protease inhibitors based on easily synthesized constrained dipeptide-like units using a structure-based approach.

Current Funding

View our currently funded projects here.

Graduate Students

Michael Doligalski, Hyun Kil, Yi Liang, Philip Murray, Fenger Zhou

Recent Publications

  1. Refereed Publications
  2. Patents
  3. In Press
  4. In Review
  5. Refereed Structural Reports
  6. Published Abstracts
  7. Thesis and Dissertations Directed

Refereed Publications: Publications after #10 are as an independent investigator. One indication of impact on the scientific discipline is the number of citations. Publications 11-39 were cited for a total of > 400 times according to the Web of Science on 9/20/01.

  1. "The Synthesis and Reactions of Potassium Benzoylphosphide, Benzoylphosphine, and Benzoylmethylphosphine" Charles L. Liotta, Mark L. McLaughlin and Brian A. O'Brien, Tetrahedron Lett., 1984, 25(12), 1249-1252.
  2. "2H-Isophosphindoline-1,3-dione Ion: The Phosphorus Analogue of Phthalimide Anion" Charles L. Liotta, Mark L. McLaughlin, Donald G. VanDerveer and Brian A. O'Brien, Tetrahedron Lett., 1984, 25(16), 1665-1668.
  3. "Methyl Transfer Reactions IX. Linear Free Energy Relations and the Reactivity-Selectivity Principle" Edward S. Lewis, Thomas A. Douglas and Mark L. McLaughlin, Isr. J. Chem., 1985, 26(4), 331-338.
  4. "Methyl Transfer Reactions X. The Marcus Equation Application to Soft Nucleophiles" Edward S. Lewis, Mark L. McLaughlin and Thomas A. Douglas, J. Am. Chem. Soc., 1985, 107(23), 6668-6673.
  5. "Synthesis of Congeners and Prodrugs of the Benzene Maleimide Photoadduct Mitindomide as Potential Antitumor Agents. 2" Howard M. Deutsch, Leslie T. Gelbaum, Mark McLaughlin, Thomas J. Fleischmann, Laurence L. Earnhart, Ronald D. Haugwitz and Le on H. Zalkow, J. Med. Chem., 1986, 29(11), 2164-2170.
  6. "Efficient Preparation of Homochiral Bicyclo-annulated Cyclopentadienes via the Skattebøl Rearrangement. Avoidance of Limitations due to Angle Strain" Mark L. McLaughlin, Jeffrey A. McKinney and Leo A. Paquette, Tetrahedron Lett., 1986 , 27(46), 5595-5598.
  7. "Transition Metal Complexation of Optically Pure Annulated Cyclopentadienes. Face Selectivity, Three-Dimensional Features and Utilization for Asymmetric Hydrogenation" Leo A. Paquette, Jeffrey A. McKinney, Mark L. McLaughlin and Alan L. Rheingol d, Tetrahedron Lett., 1986, 27(46), 5599-5602.
  8. "A Quantitative Measure of Nucleophilic Character" Edward S. Lewis, Thomas A. Douglas and Mark L. McLaughlin, Adv. Chem. Ser., 1987, 215, 35-49.
  9. "Homochiral Pinene-Fused Cyclopentadienes. Synthesis and Pi-Facially Selective Course of Diels-Alder Cycloadditions and Metallocene Formation" Leo A. Paquette, Melinda Gugelchuk and Mark L. McLaughlin, J. Org. Chem., 1987, 52(21 ), 4732-4740.
  10. "Cyclopentadiene Annulation via the Skattebøl Rearrangement: (1R)-9,9-Dimethyltricyclo[6.1.1.02,6]deca-2,5-diene." Leo A. Paquette and Mark L. McLaughlin, Organic Syntheses, 1990, 68, 220-226.
  11. "Syntheses of 1- and 2-Naphthol Analogs of DL-Tyrosine. Potential Fluorescent Probes of Peptide Structure and Dynamics in Complex Environments." Marco A. Vela, Frank R. Fronczek, Gregory W. Horn and Mark L. McLaughlin, J. Org. Chem., 1990, 55(9), 2913-2918.
  12. "DNA-Metal Binding by Antitumor-Active Metallocene Dichlorides from Inductively Coupled Plasma Spectroscopy Analysis: Titanocene Dichloride Forms DNA-Cp2Ti or DNA-CpTi Adducts Depending on pH." Mark L. McLaughlin, John M. Cronan, Jr., Tamara R. Schaller, Ronald D. Snelling, J. Am. Chem. Soc., 1990, 112(24), 8949-8952.
  13. "Tandem Reverse-Electron-Demand Diels-Alder Reactions of 1,5-Cyclooctadiene." J. Gabriel Garcia, Frank R. Fronczek and Mark L. McLaughlin, Tetrahedron Lett., 1991, 32(28), 3289-3292.
  14. "Reverse-Electron-Demand Diels-Alder Dienophile p-Face Selectivity via Conformation Dependent Transmission of p-sigma-p Electronic Interactions." J. Gabriel Garcia and Mark L. McLaughlin, Tetrahedron Lett., 1991, 32(28 ), 3293-3296.
  15. "Stereoselectivity in the Synthesis of Tetramethylethano-Bridged 3,3'-Di-tert-butyltitanocene Dichloride." Mark S. Erickson, Frank R. Fronczek and Mark L. McLaughlin, J. Organomet. Chem., 1991, 415(1), 75-85.
  16. "Improved Syntheses of Benz[f]indene" Calvin L. Becker and Mark L. McLaughlin, Synlett, 1991, (9), 642.
  17. "Syntheses of Dipentafulvenes: Bichromophoric Effects Correlated with Structure" Mark S. Erickson, John M. Cronan, Jr., J. Gabriel Garcia and Mark L. McLaughlin, J. Org. Chem., 1992, 57(8), 2504-2508.
  18. "Deuterium Isotope Effects in Constrained Tryptophan Derivatives: Implications for Tryptophan Photophysics", Lloyd P. McMahon, William J. Colucci, Mark L. McLaughlin and Mary D. Barkley, J. Am. Chem. Soc., 1992, 114(22), 844 2-8448.
  19. "Fluorescence Quenching in Indoles by Excited-State Proton Transfer", Hong-Tau Yu, William J. Colucci, Mark L. McLaughlin and Mary D. Barkley, J. Am. Chem. Soc., 1992, 114(22), 8449-8454.
  20. "Synthesis of 1,4-(1,1'-Ferrocenediyl)-1,3-butadiene: A Dieno-ferrocenophane." Mark S. Erickson, Frank R. Fronczek and Mark L. McLaughlin, Tetrahedron Lett., 1993, 34(2), 197-198.
  21. "Synthesis of Extended Linear Aromatics Using Tandem Diels-Alder Aromatization Reactions", J. Larry Morris, Calvin L. Becker, Frank R. Fronczek, William H. Daly, and Mark L. McLaughlin, J. Org. Chem., 1994, 59(21), 6484-6486.
  22. "Microenvironmental Effects on the Solvent Quenching Rate in Constrained Tryptophan Derivatives", Hong-Tao Yu, Marco A. Vela, Frank R. Fronczek, Mark L. McLaughlin, and Mary D. Barkley, J. Am. Chem. Soc., 1995, 117(1), 348-357.
  23. "Inverse-Electron Demand Diels-Alder Cyclocondensations in the Synthesis of 5-8-5 Fused Ring Systems", J. Gabriel Garcia and Mark L. McLaughlin, Org. Prep. Proc. Int., 1995, 27(1), 92-97.
  24. "A Novel Monomer and Polymers Based on 2,3,6,7-Anthracenetetracarboxylic Acid", J. Larry Morris, Mark L. McLaughlin, and William H. Daly, Macromolecules, 1995, 28(11), 3973-3979.
  25. "Routes to Conjugated Polymers with Ferrocenes in their Backbones: Synthesis and Characterization of Poly(ferrocenylene divinylene) and Poly(ferrocenylene butenylene)", Colby E. Stanton, T. Randall Lee, Robert H. Grubbs, Nathan S. Lewis, John K. Pudelski , Matthew R. Callstrom, Mark S. Erickson, and Mark L. McLaughlin, Macromolecules, 1995, 28(26), 8713-8721.
  26. "Structure-function Studies of De Novo Lytic Peptides", Mark L. McLaughlin, Maryam Javadpour, Stephen M. Bishop, Scott M. Cowell, Calvin L. Becker, Jennifer Lo, Martha M. Juban, Kathy M. Morden. Pept.: Chem., Struct. Biol., Proc. Am. Pept. Symp., 14th, (P .T.P. Kaumaya and R. S. Hodges, eds.), 1996, 569-570.
  27. "Light Scattering Study of Magnetic Latex particles and Their Interaction with Polyelectrolytes", Daewon Sohn, Paul S. Russo, Alfonso Davila, Drew Poche", and Mark L. McLaughlin, J. Colloid Interface Sci., 1996, 177(1), 31-44.
  28. "3 + 2 Cycloaddition Via a Diels-Alder/Retro-Diels-Alder Sequence: Tandem Cyclopentadienyl Annulation of a 1,5-Cyclooctadiyne Synthetic Equivalent.", Alfonso Davila, Merrikh S. Ramezanian, Frank R. Fronczek, and Mark L. McLaughlin, Tetrahedro n Lett., 1996, 37(15), 2517-2520.
  29. "De Novo Antimicrobial Peptides with Low Mammalian Cell Cytotoxicity.", Maryam Javadpour, Martha M. Juban, Wai-Chun J. Lo, Steven M. Bishop, J. Brannon Alberty, Scott M. Cowell, Calvin L. Becker, and Mark L. McLaughlin, J. Med. Chem., 1996, 39(16), 3107-3113.
  30. "Synthesis of a Water-Soluble Chiral N-acylcalix(4)arene Amino Acid Derivative", Montserrat Sanchez Pena, Yuling Zhang, Stefan Thibodeaux, Mark L. McLaughlin, Arsenio Munoz de la Pena, Isiah M. Warner, Tetrahedron Lett., 1996, 37(33), 5841-5844.
  31. "Antimicrobial a,a-Dialkylated Amino Acid Rich Peptides with In-Vivo Activity Against an Intracellular Pathogen", T. Scott Yokum, Philip H. Elzer, and Mark L. McLaughlin, J. Med. Chem., 1996, 39(19), 3603- 3605.
  32. "4-Aminopiperidine-4-carboxylic Acid: A Cyclic a,a-Disubstituted Amino Acid for Preparation of Water-Soluble Highly-Helical Peptides", Christopher L. Wysong, T. Scott Yokum, Guillermo A. Morales, Rebekah L. Gundry, Mark L. McLaughlin , and Robert P. Hammer, J. Org. Chem., 1996, 61(22), 7650-7651.
  33. "Conformer Interconversion in the Excited State of Constrained Tryptophan Derivatives: Implications for Protein Fluorescence," Lloyd P. McMahon, Hong-Tao Yu, Marco A. Vela, Guillermo A. Morales, Li Shui, Frank R. Fronczek, Mark L. McLaughlin, an d Mary D. Barkley, J. Phys. Chem., 1997, 101(16), 3269-3280.
  34. "The 310/a-Helix Equilibrium: Solvent Effects on Water-Soluble Peptides Rich in a, a-Disubstituted Amino Acids." T. Scott Yokum, Ted J. Gauthier, Robert P. Hammer, and Mark L. McLaughlin, J. Am. Chem. Soc., < b>1997, 119(5), 1167-1168.
  35. "Benz[f]tryptophan, a Bathochromic Analog of Tryptophan, Synthesis of its N-a-t-Boc Derivative." T. Scott Yokum, Paritosh K. Tungaturthi, and Mark L. McLaughlin. Tetrahedron Lett., 1997, 38(29), 5111-5114 .
  36. "Controlling Peptide Structure," Christopher L. Wysong, T. Scott Yokum, Mark L. McLaughlin, Robert P. Hammer, Chemtech, 1997, 27(7), 26-33.
  37. "Time-Resolved Fluorescence of Constrained Tryptophan Derivatives: Implications for Protein Fluorescence", Mark L. McLaughlin and Mary D. Barkley, Methods in Enzymology, 1997, 278, 190-202.
  38. The Synthesis of a Series of Orthogonally Protected, Polar, a, a-Disubstituted Amino Acids. T. Scott Yokum, Matthew G. Bursavich, Sarina A. Piha-Paul, David A. Hall, and Mark L. McLaughlin, Tetrahedron Lett., 1997, 38(23), 4013-4016.
  39. "Side-Chain Salt Bridge Stabilization of the 310-Helix." T. Scott Yokum, Matthew G. Bursavich, Ted J. Gauthier, Mark L. McLaughlin, and Robert P. Hammer, Chem. Comm., 1998, (17), 1801-1802.
  40. Synthesis and characterization of a novel tryptophan derivative. Ted J. Gauthier, Bo Liu, Guillermo A. Morales, and Mark L. McLaughlin. Pept. Proc. Am. Pept. Symp., 15th, (J.P. Tam and P.T.P. Kaumaya, eds.), 1999, 325-326,
  41. Synthesis of a Series of "Cationic", Orthogonally Protected, a, a-Disubstituted Amino Acids. T. Scott Yokum, Matthew G. Bursavich, Sarina A. Piha-Paul, David A. Hall, and Mark L. McLaughlin. Pept. Proc. Am. Pept. Symp., 15th, (J.P. T am and P.T.P. Kaumaya, eds.), 1999, 329-330.
  42. Synthesis of N-a-Boc-Benz[f]tryptophan: An Intrinsic/Extrinsic Fluorescence Probe. T. Scott Yokum, Paritosh K. Tungaturthi, and Mark L. McLaughlin Pept. Proc. Am. Pept. Symp., 15th, (J.P. Tam and P.T.P. Kaumaya, eds.), 1999, 331-332.
  43. Amphipathic a- and 310- Helical Peptides with in-vivo and in-vitro Bioactivity. Mark L. McLaughlin, T. Scott Yokum, Ted J. Gauthier, Christopher L. Wysong, Robert P. Hammer, and Philip H. Elzer. Pept. Proc. Am. Pept. Symp., 15th, (J.P. Tam and P.T.P. Kaumaya, eds.), 1999, 595-596.
  44. Antimicrobial Peptides With Activity Against an Intracellular Pathogen. T. Scott Yokum, Philip J. Elzer and Mark L. McLaughlin. Pept. Proc. Am. Pept. Symp., 15th, (J.P. Tam and P.T.P. Kaumaya, eds.), 1999, 652-653.
  45. "Fluorescence Properties of Benz[f]indole, a Wavelength and Quenching Selective Tryptophan Analog", Bo Liu, Mary D. Barkley, Guillermo A. Morales, Mark. L. McLaughlin, and Patrik R. Callis, J. Phys. Chem. B 2000, 104(12), 1837-1843.
  46. "Constrained Amino Acids in De Novo Peptide Design" Lars G. J. Hammarstrom, Ted J. Gauthier, Robert P. Hammer, Mark L. McLaughlin Pept. Proc. Am. Pept. Symp., 16th, (Greg Fields and George Barany, eds.), 2000, 272-274.
  47. "Amphipathic Control of the 310-/a-Helix Equilibrium in Synthetic Peptides", Lars G. J. Hammarstrom, Ted J. Gauthier, Robert P. Hammer, and Mark L. McLaughlin, J. Peptide Research, 2001, 58, 108-116.
  48. Yanwen Fu, Lars G.J. Hammarstrom, Tod J. Miller, Frank R. Fronczek, Mark L. McLaughlin, Robert P. Hammer, "Sterically Hindered Ca,a Disubstituted a -Amino Acids: Synthesis from a -Nitroa cetate and Incorporation into Peptides." J. Org. Chem., 2001, 66, 7118-7124.
  49. "Facile Synthesis of a Constrained Dipeptide Unit (DPU) for use as a ß-sheet promoter." Umut Oguz, Ted J. Gauthier, Mark L. McLaughlin, Pept. Proc. Am. Pept. Symp., 17th, (Michal Lebl and Richard A. Houghten, eds.), 2001, 46-4 7.
  50. "Synthesis of Novel Ferrocene Linkers for Solid Phase Synthesis of Peptides." Jose Giraldes, Mark L. McLaughlin, Pept. Proc. Am. Pept. Symp., 17th, (Michal Lebl and Richard A. Houghten, eds.), 2001, 246-247.
  51. "Selective Bioactivity of Synthetic Amphipathic Peptides Against Murine Macrophages Infected with Brucella abortus." Lars G. J. Hammarstrom, Ted J. Gauthier, Mark L. McLaughlin, Pept. Proc. Am. Pept. Symp., 17th, (Michal Lebl and Richard A. Houghten, eds.), 2001, 758-759.
  52. T. S. Yokum, R. P. Hammer, Mark L. McLaughlin, P. H. Elzer, "Peptides with indirect in vivo activity against an intracellular pathogen: selective lysis of infected macrophages." J. Peptide Res., 2002, 59, 9-17.
  53. Umut Oguz, Garett G. Guilbeau, and Mark L. McLaughlin, "A Facile Stereospecific Synthesis of a-Hydrazino Esters" Tetrahedron Lett. 43, 2873-2875 (2002).

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Patents Issued and pending:

  1. "Process for Preparation of Condensed Alcohols by Alkoxide Catalysts" D. A. Young, J. Jung, and M. L. McLaughlin, U.S. Patent No. 5,068,469.
  2. "Preparation and Antibacterial Activity of Amphipathic Peptides" M. L. McLaughlin and C. L. Becker, U.S. Patent No. 5,789,542.
  3. "Short a,a -Disubstituted Amino Acid Rich Amphipathic Peptides with Antimicrobial Activity", M. L. McLaughlin, T. S. Yokum, P. Elzer, F. Enright, and R. P. Hammer, pending since 1997.

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Publications in press:

  1. "Intramolecular Quenching of Tryptophan Fluorescence by the Peptide Bond in Cyclic Hexapeptides" Paul D. Adams, Yu Chen, Ma Kan, Michael G. Zagorski, Frank D. Sonnichsen, Mark L. McLaughlin, Mary D. Barkley, submitted to J. Am. Chem. Soc.

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Publications in review:

  1. "1-tert-Butyloxycarbonyl-4-((9-fluorenylmethyloxycarbonyl)amino)-piperidine-4-carboxylic acid. A Convenient Preparation of an Orthogonally Protected a, a-Disubstituted Amino Acid Derivative of Lysine", Lars G. J. Hammarstrom and Mark L. McLaughlin, accepted for checking for possible publication in Organic Syntheses.
  2. "Helix Design Influences on the Selective Bioactivity of Synthetic Amphipathic Peptides Against Murine Macrophages Infected with Brucella Abortus." Lars G. J. Hammarstrom, Ted J. Gauthier, Philip H. Elzer, Sue D. Hagius, Natha J. Booth, F rederick M. Enright, Mark L. McLaughlin, submitted to J. Peptide Res.
  3. "Fluorescence of a-1-Amino-2-(3-Indolyl)cyclohexanecarboxylic Acid: a Single Tryptophan ?1 Rotamer Model." Bo Liu, Reema K. Thalji, Paul D. Adams, Frank R. Fronczek, Mark L. McLaughlin, Mary D. Barkley, submitted to J. Am . Chem. Soc.

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Refereed Structural Reports:

  1. "Reactions of 1,1'-Dilithioferrocene with Diketones: 1-Ferrocenyl-5-hydroxy-9-oxabicyclo[3.3.1]nonane" Frank R. Fronczek, John M. Cronan, Jr. and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1988, C44( 4), 636-638.
  2. "A Dipentafulvene with Head-to-Head Geometry" Mark L. McLaughlin, John M. Cronan, Jr. and Frank R. Fronczek, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1988, C44(10), 1747-1749.
  3. "5-(2,4-Cyclopentadien-1-ylidene)cyclooctanone, A Bichromophoric Molecule." John M. Cronan, Jr., Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1989, C45(7), 1063-1065.
  4. "An Aminocyclohexanecarboxylic Acid." Marco A. Vela, Mark L. McLaughlin and Frank R. Fronczek, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1989, C45(7), 1091-1093.
  5. "2-(2,4-Cyclopentadien-1-ylidene)adamantane." J. Gabriel Garcia, Mark L. McLaughlin and Frank R. Fronczek, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1989, C45(7), 1099-1100.
  6. "The Mono Diels-Alder Adduct of 1,4-Bis(2,4-cyclopentadien-1-ylidene)cyclohexane with Dimethyl Butynedioate" Frank R. Fronczek, Mark L. McLaughlin and John M. Cronan, Jr., Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1989, < i>C45(8), 1184-1186.
  7. "A Tetramethylethano Bridged Difulvene" Mark S. Erickson, Mark L. McLaughlin and Frank R. Fronczek, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1989, C45(8), 1260-1261.
  8. "A Bichromophoric Difulvene from 1,5-Cyclooctadione" Frank R. Fronczek, John M. Cronan, Jr. and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1990, C46(5), 920-921.
  9. "A Bichromophoric Difulvene from 3,7-Bicyclo[3.3.0]octadione" John M. Cronan, Jr., Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1990, C46(6), 1176-1178.
  10. "9-(2,4-Cyclopentadienylidene)bicyclo[3.3.1]nonane, A Ring Strained Pentafulvene" Frank R. Fronczek, J. Gabriel Garcia and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1990, C46(6), 1181-1183.
  11. "The syn Tetramethylethano-Bridged 3,3'-Di-tert-butyltitanocene Dichloride" Mark S. Erickson, Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1990, C46(10), 1802-1804.
  12. "(4S, 5S)-[bis-(Pyrrolidylamide)]-2,2-dimethyl-1,3-dioxolane" J. Gabriel Garcia, Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1991, C47(1), 202-204.
  13. trans-1,5-Bicyclo[4.4.0]decadione" J. Gabriel Garcia, Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1991, C47(1), 204-206.
  14. "The endo-endo Diels-Alder Diadduct of 5,5-Dimethoxy-1,2,3,4-tetrachloro-1,3-cyclopentadiene with 1,5-Cyclooctadiene (1) and the Dechlorinated Diels-Alder Diadduct (2)" J. Gabriel Garcia, Frank R. Fronczek, Mark L. McLaughlin, Acta Crystallog r., Sect. C: Cryst. Struct. Commun., 1991,C47(1), 206-209.
  15. "The Major Diels-Alder Diadduct of 1,2,3,4-Tetrachloro-1,3-cyclopentadiene with 1,5-Cyclooctadiene" J. Gabriel Garcia, Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1991, C47(2), 451-453.
  16. "The Diels-Alder Diadduct of Hexachlorocyclopentadiene with Cyclooctatetraene", Gabriel J. Garcia, Rosa G. Reza-Garduno, Frank R. Fronczek, Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1991, C47(8), 1771-177 4.
  17. "N-Tosyl)-8-azaspiro[4.5]deca-1,3-diene" J. Gabriel Garcia, Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1991, C47(9), 1989-1991.
  18. "Tricyclo[8.2.1.02,9]trideca-5,11-diene-13-one" J. Gabriel Garcia, Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1991, C47(9), 1998-2000.
  19. "Pentacyclo[12.2.1.16,9.02,13.05,10.]octadeca-7,15-diene-17,18-dione" J. Gabriel Garcia, Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1991, C47(9), 2009-2011.
  20. "2-Thia[3]ferrocenophane S-Oxide." Mark S. Erickson, Yanhui Yu, Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1991, C47(12), 2668-2669.
  21. "3-Benzoyl-1-Tosylpyrrole." Mark S. Erickson, Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1992, C48(1), 202-203.
  22. "The Major Diels-Alder Adduct of 1,2,3,4-Tetrachloro-1,3-cyclopentadiene with 1,9,10,11-Tetrachloro-12,12-dimethoxytricyclo[8.2.1.02,8]dodeca-5,10-diene." J. Gabriel Garcia, Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C : Cryst. Struct. Commun., 1992, C48(1), 197-199.
  23. "1,8,9,10,11,18,19,20,21,23,23-Dodecachloroheptacyclo[16.2.1.13,16.18,11.02,17.04,15.07,12]trieicosa-9,19-diene." J. Gabriel Garcia, Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1992 , C48(1), 195-197.
  24. "The 1:1 Diels-Alder Adduct of 1,5-Cyclooctadiene and 5,5-Dimethoxy-1,2,3,4-tetrachloro-1,3-cyclopentadiene." Jingyi Li, Frank R. Fronczek and Mark L. McLaughlin, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1992, C48(1), 200-201.
  25. "The Structure of a Tetrabromotetrahydrodibenzocyclooctene.", Tamara R. Nauman, Mark L. McLaughlin, Frank R. Fronczek, and Steven F. Watkins, J. Chem. Cryst., 1996, 26, 107-110.
  26. "Two Cyclohexanespiro-5'-hydantoin monohydrates", Ted J. Gauthier, T. Scott Yokum, Guillermo A. Morales, Mark L. McLaughlin, Yen-Hsiang Liu, Frank R. Fronczek, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1997, C53(11), 1659-1661.
  27. "1,5-Dibromocycloocta-1,5-diene", Alfonzo Davila, Mark L. McLaughlin, Frank R. Fronczek and Steven F. Watkins, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 1997, C53(, 84-86.
  28. "2-Nitro-N,N-bis(2-nitrophenylthio)benzsulfonamide", Umut Oguz, Mark L. McLaughlin, and Frank R. Fronczek, Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 2000, C56(1), e27-e28.
  29. "Two N-ortho-nitrobenzenesulfonyl a,a-disubstituted amino acid adducts." Hammarstrom, Lars G. J.; Zhang, Tao; Giraldes, Jose; McLaughlin, Mark L.; Billodeaux, Damon R.; Fronczek, Frank R. Acta Crystallogr., Sect. C: Cryst. Struct. Co mmun. 2000, C56, 1484-1486.
  30. "Ne-Benzyloxycarbonyl-Na-(2-nitrobenzenesulfonyl)-L-lysine", Jose Giraldes, Mark L. McLaughlin, Frank R. Fronczek, Acta Crystallogr, Sect E: Struct. Rep. Online, 2001, E57, o48-o49.
  31. "2-Propenyl 4-ferrocenyl-4-oxobutanoate.", Giraldes, Jose; McLaughlin, Mark L.; Fronczek, Frank R. Acta Crystallogr, Sect E: Struct. Rep. Online, 2001, E57, m426-m427.
  32. "1-Benzoyl-2(S)-tert-butyl-4-methoxy-6(S)-carbomethoxy-1,2,5,6-tetrahydro-1,3-pyrimidine: a useful precursor of a-alkylated aspartic acids.", Giraldes, Jose; McLaughlin, Mark L.; Fronczek, Frank R. Acta Crystallogr, Sect. E: Struct. Rep. O nline 2002, E58, o261-o262.

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Published abstracts (#) and invited talks (*) since 1987:

* McLaughlin, M. L. "The Synthesis of Chiral Titanocene Complexes and Asymmetric Catalytic Hydrogenation" The Madri Gras Symposium, Baton Rouge, Louisiana, 3/87.
* McLaughlin, M. L. "Nickel Catalyzed Coupling of Diynes" Southwest Regional Organometallic Workshop, Norman, Oklahoma, 5/87.
# Vela, M. A.; McLaughlin, M. L.; Tilstra, L.; Barkley, M. D. "Tyrosine derivatives as fluorescence probes of peptide structure" Organic Division of the 197th American Chemical Society Meeting, Dallas, Texas, 4/89.
# Cronan, J. M., Jr.; McLaughlin, M. L.; Snelling, R. D. "Indirect evidence for DNA binding by metallocenes" Inorganic Division of the 197th American Chemical Society Meeting, Dallas, Texas, 4/89.
# Erickson, M. S.; McLaughlin, M. L.; Fronczek, F. R. "Unprecedented syn selectivity in the synthesis of bridged titanocene dichloride derivatives" Inorganic Division of the 197th American Chemical Society Meeting, Dallas, Texas, 4/89.
* Schaller, T. R.; McLaughlin, M. L. "The DNA-Titanium Complex Derived from Titanocene Dichloride." Biochemistry Division of the 45th Southwest Regional ACS Meeting, Baton Rouge, Louisiana, 12/89.
Yu, Y.; McLaughlin, M. L. "Synthesis of Ferrocenophanes and a Ferrocenophene." Organic Division of the 45th Southwest Regional ACS Meeting, Baton Rouge, Lousiana, 12/89.
Vela, M. A.; McLaughlin, M. L. "Asymmetric Hydrogenation of 3-Naphthylacrylic Acids." Organic Division of the 45th Southwest Regional ACS Meeting, Baton Rouge, Lousiana, 12/89.
Young, D. A.; Jung, J. A.; McLaughlin, M. L. "Mechanism of the Guerbet Dimerization of Primary Alcohols." Organic Division of the 45th Southwest Regional ACS Meeting, Baton Rouge, Louisiana, 12/89.
Garcia, J. G.; McLaughlin, M. L. "The Synthesis of Chiral Difulvenes." Organic Division of the 45th Southwest Regional ACS Meeting, Baton Rouge, Louisiana, 12/89.
# Barkley, M. D.; Tilstra, L.; Vela, M. A.; McLaughlin, M. L. Struct. Methods, Proc. Converstion Discip. Biomol. Stereodyn., 6th, 1990, 2, 139-145.
* McLaughlin, M. L. "Ferrocenophene and Potential Routes to Other Theoretically Interesting Ferrocenes" 14th Annual National Science Foundation Organometallic Workshop, Lexington, KY, 5/90.
# McLaughlin, M. L.; Schaller, T. R. "An Intact Biscyclopentadienyltitanium(IV) Moiety Binds DNA." Inorganic Division of the 200th ACS National Meeting, Washington, DC, 8/90.
# Garcia, J. G.; McLaughlin, M. L. "Diels-Alder Diadducts of Electron Poor Cyclopentadienes and 1,5-Cyclooctadiene." Organic Division the 200th ACS National Meeting, Washington, DC, 8/90.
McLaughlin, M. L.; Garcia, J. G. "Diels-Alder Dienophile Face Selectivity from Reactions of Cyclooctenes with Electron Deficient Dienes." 42nd Southeast/46th Southwest Combined Regional Meeting of the American Chemical Society, New Orleans, LA, 12/90.
Schaller, T. R.; McLaughlin, M. L. "pH Dependence, Stability, and Kinetics of the DNA-Ti Binding from the Antitumor Agent, Titanocene Dichloride." 42nd Southeast/46th Southwest Combined Regional Meeting of the American Chemical Society, New Orleans, LA, 12/90.
* McLaughlin, M. L. "Two Cp or not Two Cp? Titanocene-DNA Binding." 3rd Annual J. J. Zuckermann Organometallic Workshop, Norman, Oklahoma, 5/91.
# "Cyclopentadienylation of Strained Cycloalkynes." M. L. McLaughlin, A. Davila, T. R. Schaller and G. A. Morales, Organic Division, 204th ACS Meeting, Washington, D. C., 8/92.
# "New Syntheses of Benz[f]indene, 2,3,6,7-Dibenzfluorenone, and 2,3,6,7-Tetrasubstituted Anthracenes." C. L. Becker, J. L. Morris, W. J. Daly, M. L. McLaughlin, Organic Division, 204th ACS Meeting, Washington, D. C., 8/92.
# "Synthesis of 1,4-(1,1'-ferrocenediyl)-1,3-butadiene" M. S. Erickson and M. L. McLaughlin, Organic Division, 204th ACS Meeting, Washington, D. C., 8/92.
# "Synthesis of 2-Amino-2-cyclopenta[2,3]indolecarboxylic Acid", L. Shui and M. L. McLaughlin, Organic Division, 204th ACS Meeting, Washington, D. C., 8/92.
# "A Reactive Monomer and Polymer Containing the 2,3,6,7-Anthracenetetracarboxyl Unit", J. L. Morris, M. L. McLaughlin, W. H. Daly, Polym. Prepr., 1994, 35(1), 555-556.
# "Investigating the Secondary Structure of Designed Amphiphilic Peptides", M. Javadpour, C. L. Becker, S. M. Cowell, M. L. McLaughlin, M. M. Juban, K. M. Morden, Biophysical Society Meeting, New Orleans, 4/94.
# "Highly Repetitive Amphiphilic Peptides Designed with Two Distinct Leucine Zipper Binding Domains", S. M. Cowell, J. C. Hogan, C. L. Becker, M. L. McLaughlin, M. M. Juban, Biophysical Society Meeting, New Orleans, 4/94.
* "1,4-(1,1'-Ferrocenediyl)-1,3-butadiene: a Potential ROMP Monomer to Ferrocene-Diene Polymers." Mark L. McLaughlin, Organometallic Gordon Conference, 6/94.
"Structure-Function Studies of De Novo Lytic Peptides", M. L. McLaughlin, 14th American Peptide Symposium, Columbus, Ohio, 6/95.
"A Novel Synthesis of (L)-Pyrenylalanine with Incorporation into Amphipathic Peptides in Order to Determine Aggregation States via Fluorescence Spectroscopy", S. M. Cowell, S. Bishop, and M. L. McLaughlin, 14th American Peptide Symposium, Columbus, Ohio, 6/95.
"Lytic Peptide-Calixarene Conjugates", T. S. Yokum, T. J. Gauthier, and M. L. McLaughlin, 14th American Peptide Symposium, Columbus, Ohio, 6/95.
* "Design of Novel Antimicrobial Peptides", Mark L. McLaughlin, College of Science, Christian Brothers University, Memphis, TN, 4/96.
* Antimicrobial Drugs for the Next Millenium" Mark L. McLaughlin, Department of Chemistry, LSU, 11/96.
"A Design of a New Linker for Peptide Synthesis", Ayisha T. Dabre, T. Scott Yokum, and Mark L. McLaughlin, Proc. NOBCChE, 1997, 24, 177-179.
*# Amphipathic a- and 310- Helical Peptides with in-vivo and in-vitro Bioactivity. Mark L. McLaughlin, 15th American Peptide Symposium, Nashville, TN, 6/97.
* "Novel Amino Acids in the Design of Highly Helical Peptides with Enhanced Biological Activity", Mark L. McLaughlin, Department of Chemistry, Case Western Reserve University, Cleveland, OH, 4/99.
*# "Highly Helical Peptides with Enhanced Biological Activity", Mark L. McLaughlin, 16th American Peptide Symposium, Minneapolis, MN, 6/99.
* "Constrained Amino Acids Designed to Stabilize Peptide Conformations and Enhance Bioactivity", Mark L. McLaughlin, University of South Florida and H. Lee Moffitt Cancer Center, Tampa, FL, 9/01.

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Graduate Students, Thesis and Dissertations Directed:

  1. John M. Cronan, Jr. MS, December 1988; "Complexation of Deoxyribonucleic Acids by Antitumor Metallocene(IV) Compounds and Other Transition Metal Complexes and The Synthesis of Fulvenes from Various Cyclic Diones". Mr. Cronan earned a Ph.D. with Prof. John L. Cardelina, II from Montana State University.
  2. Marco A. Vela, Ph.D., December 1989; "The Synthesis of Constrained and Benzannulated Derivatives of the Essential Amino Acids Tyrosine and Tryptophan". Dr. Vela is a Research Chemist at SunPure Products, in Northern Florida.
  3. J. Gabriel Garcia, Ph.D., December 1990; "Synthesis of Cyclopentadienyl Derivatives. Stereoelectronic Effects in the Diels-Alder Cyclocondensation Reaction". Dr. Garcia is a Research Chemist working for a combinatorial chemistry company in Germany.
  4. Mark S. Erickson, Ph.D. December 1992; "Synthesis of Novel Metallocenes: Asymmetric Hydrogenation Catalysts to Conductive Polymers." Dr. Erickson is currently an Assistant Professor in the Department of Chemistry, Hartwick College, Oneonta, NY.
  5. Tamara R. (Schaller) Nauman, Ph.D., May 1994; Titanocene/DNA Binding and the Synthesis and Characterization of Bridged Cyclopentadienes for the Preparation of Novel Titanocenes, Dr. Nauman is an instructor in the Department of Chemistry, LSU.
  6. Calvin L. Becker, Ph.D., May 1994; The Design, Synthesis and Structure-Function Studies of Highly Repetitive Amphiphilic Antibacterial Peptides and the Synthesis of Benz[f]indene for the Preparation of Novel Metallocenes, Dr. Becker is a Research Chemist at Abbott Laboratories, North Chicago, IL.
  7. Li Shui, Ph.D., December 1994; The Synthesis of Tryptophan and Tyrosine Derivatives. Dr. Shui is a Research Chemist in Shanghai, PRC.
  8. Guillermo Morales, Ph.D., May 1995; Synthesis of Benz[f]tryptophan and Constrained Amino Acid Derivatives as Fluorescence Probes. Dr. Morales was a postdotoral fellow at Dupont-Merck Pharmaceuticals with Drs. William DeGrado and Paul Anderson. He is now a Research Chemist at Guilford Pharmaceuticals, Maryland.
  9. Alfonso Davila, Ph.D., August 1996; Synthesis of Novel Cyclopentadienyl and Pyrrole Compounds. Dr. Davila is an instructor in the Department of Chemistry, LSU.
  10. Scott M. Cowell, Ph.D., May 1997; Synthesis of Novel Amino Acids with Incorporation into Peptides and Synthesis of Peptides with Novel Aggregation States. Dr. Cowell currently holds a competitive NIH Postdoctoral Fellowship with Prof. Victor Hruby, Department of Chemistry, University of Arizona.
  11. T. Scott Yokum, Ph.D., May 1998; Synthesis of Novel Amino Acids and 310- and a-Helical a,a-Disubstituted Amino Acid Rich Antimicrobial Peptides. He recently completed a competitive NIH Postdoctoral Fellowship with Prof. George Barany, Department of Chemistry, University of Minnesota. He is now a Research Chemist at TransTech Prarmaceuticals, North Carolina.
  12. Ted J. Gauthier, Ph.D., August 2000; Novel Amino Acids for the Stabilization of Helical and Beta-sheet Forming Peptides. Dr. Gauthier was awarded a competitive NIH Postdoctoral Fellowship with Prof. Daniel Rich, Department of Chemistry, University of Wisconsin, Madison, but elected to take a job as a Research Chemist at Rohm & Haas, Pennsylvania.
  13. Lars J. G. Hammarstrom, Ph.D. 2001; "Synthetic Peptides: Design, Structure, and Biological Function." Dr. Hammarstrom was awarded the Coates Outstanding Dissertation. He has taken an industrial postdoctoral position with Roche Biosciences in Palo Alto, CA working on amino acid synthesis and metalloprotease design.

Umut Oguz, Ph.D. student since 1998.
Jose Giraldes, Ph.D. student since 1998.
Caleb Clark, Ph.D. student since 2001.

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