Department of Chemistry
University of South Florida
4202 E. Fowler Avenue, CHE 205A
Tampa, FL 33620-5250
Office: (813) 974-0014, NES 405A
Lab: (813) 974-7365, NES 405
Email: mmclaugh@cas.usf.edu
B.S. in Chemistry, Christian Brothers College, Memphis, TN, 1979
Ph.D. in Organic Chemistry, Georgia Institute of Technology, 1983
Dissertation:
Synthesis and Reactions of Aroylphosphides and Lewis Acid Catalyzed Aldol Condensations
Advisor: Charles L. Liotta
Postdoctoral Research -
Physical Organic Chemistry, Rice University, 1983-85
Mentor: Edward S. Lewis
Postdoctoral Research -
Synthetic Organic Chemistry, The Ohio State University, 1985-86
Mentor: Leo A. Paquette
We are investigating: short highly helical amphipathic peptides with direct and indirect antimicrobial activity and anticancer activity and constrained dipeptides that enforce an extended conformation for use in the synthesis of stable beta-sheet-like peptide structures with applications to age-related disease such as Alzheimer's and Parkinson's disease. We are developing a new class of HIV protease inhibitors based on easily synthesized constrained dipeptide-like units using a structure-based approach.
Laura Anderson, David Badger, Priyesh Jain, Philip Murray, Melissa Topper, Mingzhou Zhou