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Department of Chemistry

Selected Publications

  1. “Structure-Activity Relationships of N-Methylthiolated β-Lactam Antibiotics with C3 Substitutions and Their Selective Induction of Apoptosis in Human Cancer Cells,” Deborah Kuhn, Yang Wang, Vesna Minic, Cristina Coates, G.. Suresh Kumar Reddy, Kenyon G.. Daniel, Jeung-Yeop Shim, Di Chen, Kristin R. Landis-Piwowar, Fred R. Miller, Edward Turos, and Q. Ping Dou, Frontiers in Bioscience, 10, 1183-1190 (2005).
  2. “Microbiological Properties and Modes of Action of Organosulfur-Based Anti-infectives,” Bart Heldreth and Edward Turos, Current Medicinal Chemistry-Anti-Infective Agents, 4, 295-315 (2005).
  3. “N-Methylthio β-Lactam Antibacterials: Effects of the C3/C4 Ring Substituents on Anti-MRSA Activity,” Edward Turos, Cristina Coates, Jeung-Yeop Shim, Yang Wang, J. Michelle Roettgers, Timothy E. Long, G. Suresh Kumar Reddy, Alex Ortiz, Marci Culbreath, Sonja Dickey, Daniel V. Lim, Eduardo Alonso and Javier Gonzalez, Bioorganic and Medicinal Chemistry, 13, 6289-6308 (2005).
  4. “β-Lactams,” Cristina Coates, Jasmine Kabir, and Edward Turos, Compounds with Four and Three Carbon-Heteroatom Bonds, Science of Synthesis, Houben-Weyl Methods of Molecular Transformations, Volume 21, Section 21.9, 609-646 (2005).
  5. “N-Thiolated 2-Oxazolidinones: A New Family of Antibacterial Agents for Methicillin-Resistant Staphylococcus aureus (MRSA) and Bacillus anthracis,” Rajesh K. Mishra, Kevin D. Revell, Cristina M. Coates, Edward Turos, Sonja Dickey, Daniel V. Lim, Bioorganic and Medicinal Chemistry Letters, 16, 2081-2083 (2006).
  6. “N-Thiolated β-Lactams: A New Family of anti-Bacillus Agents,” Edward Turos, Timothy E. Long, Bart Heldreth, Jeanne M. Leslie, Suresh K.R. Guntireddygari, Yang Wang, Cristina Coates, Monika Konaklieva, Sonja Dickey, Daniel V. Lim, Eduardo Alonso, Javier Gonzalez, Bioorganic and Medicinal Chemistry Letters, 16, 2084-2090 (2006).
  7. “N-Thiolated β-Lactam Antibacterials: Effects of the N-Organothio Substituent on anti-MRSA Activity,” Bart Heldreth, Timothy E. Long, Seyoung Jang, Suresh K.R. Guntireddygari, Edward Turos, Sonja Dickey, Daniel V. Lim, Bioorganic and Medicinal Chemistry, 14, 3775-3784 (2006).
  8. “Antibiotic-Conjugated Polyacrylate Nanoparticles: New Opportunities for Development of Anti-MRSA Agents,” Edward Turos, Jeung-Yeop Shim, Yang Wang, Kerriann Greenhalgh, G. Suresh Kumar Reddy, Sonja Dickey, Daniel V. Lim, Bioorganic and Medicinal Chemistry Letters, 17, 53-56 (2007).
  9. ”N-Thiolated β-Lactams: Studies on the Mode of Action and Identification of a Primary Cellular Target in S. aureus,” Kevin D. Revell, Bart Heldreth, Timothy E. Long, Seyoung Jang, and Edward Turos, Bioorganic and Medicinal Chemistry, 15, 2453-2467 (2007).
  10. “Synthesis of 2-Oxazolidinones from β-Lactams: Stereospecific Total Synthesis of (-)-Cytoxazone and All of its Stereoisomers,” Rajesh Kumar Mishra, Cristina M. Coates, Kevin D. Revell, and Edward Turos, Organic Letters, 9, 575-578 (2007).
  11. “Glycosylated Polyacrylate Nanoparticles by Emulsion Polymerization,” Sampath Abeylath and Edward Turos, Carbohydrate Polymers, 70, 32-37 (2007).
  12. “Penicillin-Bound Polyacrylate Nanoparticles: Restoring the Activity of β-Lactam Antibiotics Against MRSA,” Edward Turos, G. Suresh Kumar Reddy, Kerriann Greenhalgh, Praveen Ramaraju, Sampath C. Abeylath, Seyoung Jang, Sonja Dickey, Daniel V. Lim, Bioorganic and Medicinal Chemistry Letters, 17, 3468-3472 (2007).
  13. “Total Syntheses of (-)-a-Kainic Acid and (+)-a-Allokainic Acid via Stereoselective C-H Insertion and Efficient 3,4-Stereocontrol,” Young Chun Jung, Cheol Hwan Yoon, Edward Turos, Kyung Soo Yoo, and Kyung Woon Jung, Journal of Organic Chemistry, 72, 10114-10122 (2007).
  14. “Glyconanobiotics: Novel Carbohydrated Nanoparticle Antibiotics for MRSA and Bacillus anthracis,” Sampath Abeylath, Edward Turos, Sonja Dickey, and Daniel V. Lim, Bioorganic and Medicinal Chemistry, 16, 2412-2418 (2008).
  15. “Methods for Purifying and Detoxifying Sodium Dodecyl Sulfate-Stabilized Polyacrylate Nanoparticles,” Julio C. Garay-Jimenez, Ashley Young, Danielle Gergeres, and Edward Turos, Nanomedicine: Nanotechnology, Biology, and Medicine, 4, 98-105 (2008).
  16. “In vivo Studies of Polyacrylate Nanoparticle Emulsions for Topical and Systemic Applications,” Kerriann Greenhalgh and Edward Turos, Nanomedicine: Nanotechnology, Biology, and Medicine, in press (2008).
  17. “Anti-tumor Activity of N-Thiolated β-Lactam Antibiotics,” Di Chen, Samuel C. Falsetti, Michael Frezza,Vesna Milacic, Aslamussaman Kazi, Qiuzhi Cindy Cui, Timothy E. Long, Edward Turos, and Q. Ping Dou, Cancer Letters, 268, 63-69 (2008).
  18. “Drug Delivery Approaches to Overcome Bacterial Resistance to β-Lactam Antibiotics,” Sampath C. Abeylath and Edward Turos, Expert Opinion on Drug Delivery, 5, 931-949 (2008).
  19. “Studies on the Antifungal Properties of N-Thiolated β-Lactams,” Marci O'Driscoll, Kerriann Greenhalgh, Ashley Young, Edward Turos, Sonja Dickey, and Daniel V. Lim, Bioorganic and Medicinal Chemistry, 16, 7832-7837 (2008).
  20. “Unsymmetrical Aryl-alkyl Disulfide Growth Inhibitors of Methicillin-resistant Staphylococcus aureus and Bacillus anthracis,” Edward Turos, Kevin D. Revell, Praveen Ramaraju, Danielle Gergeres, Kerriann Greenhalgh, Ashley Young, Sonja Dickey, Daniel Lim, Nalini Sathyanarayan, Mamoun M. Alhamadsheh, and Kevin Reynolds, Bioorganic and Medicinal Chemistry, 16, 6501-6508 (2008).
  21. “Induction of Tumor Cell Apoptosis by a Novel Class of N-Thiolated β-Lactam Antibiotics with Structural Modifications at N1 and C3 of the Lactam Ring,” Michael Frezza, Julio Garay, Di Chen, Cindy Cui, Edward Turos, and Q. Ping Dou, International Journal of Molecular Medicine, 21,:689-695 (2008).